Levonorgestrel – a synthetic progestogen with contraceptive action, progestin and pronounced antiestrogenic properties. At the recommended dosing regimen, levonorgestrel inhibits ovulation and fertilization if intercourse occurred in the pre-ovulatory omnadren phase, when the possibility of fertilization is the highest. It can also cause changes in the endometrium which prevent implantation. The drug is not effective if implantation has already occurred. Efficiency: Using Postinor tablets can prevent pregnancy in about 85% of cases. The longer the time elapsed between the reception of sexual intercourse and the drug, the lower its efficiency (95% for the first 24 hours, 85% – from 24 to 48 hours, and 58% -. 48 to 72 hours).
Thus, the reception postinor pills is recommended to start as soon as possible (but no later than 72 hours) after sex, if you do not use any protective measures. The recommended dose of levonorgestrel has no significant effect on blood clotting factors, fat and carbohydrate metabolism. After oral reception levonorgestrel is rapidly and almost completely absorbed. After receiving 0.75 mg levonorgestrel maximum drug concentration in serum equal to 14.1 ng / ml is reached after 1.6 hours. After the maximum concentration level of levonorgestrel content decreases and the half-life is about 26 hours. levonorgestrel derived approximately equally via the kidneys and intestines exclusively in the form of metabolites. Biotransformation Levonorgestrel corresponds to metabolize steroids.Levonorgestrel is hydroxylated in the liver and the metabolites are excreted in the form of glucuronide conjugate. Levonorgestrel pharmacologically active metabolites are unknown. Levonorgestrel binds serum albumin and globulin, sex hormone binding (SHBG). Only 1.5% of the dose is in the free form while 65% is bound to SHBG. The absolute bioavailability is nearly 100% of the dose.
Emergency (postkontalnaya) contraception (after unprotected intercourse or contraceptive method used unreliability).
Hypersensitivity to any component of the drug, the use in adolescents under 16 years, severe hepatic failure, pregnancy.
Patients with rare hereditary conditions such as lactose intolerance, lactase deficiency or glucose-galactose malabsorption.
of liver disease or bile ducts, jaundice (including history), Crohn’s disease, lactation.
Pregnancy and lactation
postinor not be used during pregnancy. If omnadren pregnancy has arisen in the application of the emergency contraceptive method, on the basis of the available data the adverse effect of the drug on the fetus have been identified.
Levonorgestrel gets into breast milk. After taking the drug breast-feeding should be discontinued for 24 hours.
DOSAGE AND ADMINISTRATION
The drug is administered orally. You must take 2 tablets in the first 72 hours after unprotected intercourse. The second tablet should be taken 12 hours (but not later than 16 hours) after taking the first pill.
In order to achieve a more reliable effect of the two pills should be taken as soon as possible after unprotected intercourse (not later than 72 h).
If the within three hours after receiving 1 or 2 tablets Posti’s time vomiting occurs, you should take another pill Postinor.
postinor can be used at any time of the menstrual cycle. In the case of irregular menstrual cycle pre-pregnancy must be excluded.
After taking emergency contraceptive before the next menstrual period should apply local barrier methods of birth control (such as a condom, cervical cap). Use of the drug with repeated unprotected sex during the same menstrual cycle is not recommended due to increased frequency of acyclic spotting / bleeding.
Allergic reactions: urticaria, rash, itching, swelling of the face.
Transient side effects that occur with varying frequency (frequent: ≥1 / 100, <1/10, very common: ≥1 / 10) and do not require drug therapy: common: vomiting, diarrhea, dizziness, headache, breast tenderness, delayed menstruation (no more than 5-7 days), if menstruation is delayed for a longer period, it is necessary to exclude pregnancy.
Very common: nausea, fatigue, abdominal pain, acyclic spotting (bleeding).
Increased severity of side effects. No specific antidote. Treatment – symptomatic.
Interaction with other drugs
With simultaneous reception of preparations inducers of liver enzymes occurs accelerating metabolism of levonorgestrel.
The following drugs may reduce the effectiveness of Levonorgestrel: amprenavir, lansoprazole, nevirapine, oxcarbazepine, tacrolimus. topiramate, tretinoin, barbiturates, including primidone, phenytoin, and carbamazepine; preparations containing St. John’s wort (Hypericum perforatum), and rifampicin. ritonavir, ampicillin, tetracycline, rifabutin. griseofulvin. Reduces the effectiveness of hypoglycemic and anticoagulant (coumarin derivatives, phenindione) drugs. It increases plasma concentrations of glucocorticoids. Women taking these drugs should consult a doctor. Preparations containing levonorgestrel may increase the risk of cyclosporin toxicity due to the suppression of its metabolism.
postinor should be used only for emergency contraception! Repeated use of the drug is not recommended in postinor within one menstrual cycle!
Efficiency postinor pills after omnadren unprotected sex, which does not use contraceptives, decreases with time:
The drug does not replace the use of regular contraceptive methods. In most cases Postinor not affect the nature of the menstrual cycle. However, you may receive the acyclic bleeding and delay menstruation for several days. When you delay menstruation for more than 5-7 days and change its nature (allocation of scarce or abundant) should be deleted pregnancy. The emergence of lower abdominal pain, fainting may indicate an ectopic (ectopic) pregnancy.
Teenagers up to 16 years in exceptional cases (including rape) should consult a gynecologist to confirm the pregnancy.
After the emergency contraception is recommended
Emergency contraception omnadren does not protect against sexually transmitted diseases by. consulting a gynecologist for the selection of the most appropriate method for permanent contraception.
When violations of the gastrointestinal tract function (eg, Crohn’s disease) the effectiveness of the drug can be reduced. buy cjc1295