It has a hyperosmotic laxative effect, stimulates peristalsis, improves the absorption of calcium and phosphate, promotes the excretion of ammonium ions. Under the influence of multiplication occurs lactulose Lactobacillus acidophilus, testosterone blend 250mg bifidus in the intestine, which in turn leads to a decrease in pH in the lumen of colonic motility and activating it. Along with this increased volume and stool softening. The drug has a laxative effect, without affecting directly to the mucosa and the smooth muscles of the colon.
Under the influence of lactulose reduces the formation of nitrogen-containing toxic substances in the proximal colon and their absorption into the systemic circulation. The concentration of ammonium ions in the blood is reduced by 25 – 50%, reduces the severity of hepatic encephalopathy, improves mental state and normalizes the EEG.
The drug has the ability to inhibit the growth of Salmonella in the large intestine. Effect of the drug occurs within 24-48 hours after ingestion of the drug as it passes through the gastrointestinal tract.
Lactulose is practically not absorbed from the gastro-intestinal tract (not absorbed more than 3% of the dose) does not reduce the absorption of vitamins, non-addictive.
- constipation (including chronic)
- the need to soften the stool for medical purposes (hemorrhoids, need surgery on the colon and / or anus, pain after the removal of hemorrhoids, post-operative period)
- intestinal dysbiosis
- Hepatic encephalopathy
- hepatic coma and precoma (treatment and prevention) hyperammonemia;
- enteritis caused by Salmonella, Shigella, salmonellonositelstvo;
- putrefactive dyspepsia syndrome (in infants from acute food poisoning).
Hypersensitivity to lactulose or any other components of the drug, galactosemia, ileus, rectal bleeding (which is not a cause of hemorrhoids), colorectal, ileostomy, suspected appendicitis.
Adults and children over 7 years 5 – 10 ml of syrup (1-2 teaspoons)The drug is best taken in the morning during or after a meal, once or divided into two reception. The drug can be washed down with water or other liquid. The patient can select and change the dose and time of receipt by the needs of the drug. The laxative effect of the drug develops within the first two days of admission. Duration of treatment for constipation is from 4 weeks to 3-4 months. In the treatment of liver (portal) encephalopathy, hepatic coma and precoma: . 30-50 ml of syrup (2-3 tablespoons) three times a day in the initial phase of treatment can be administered dose of 30-45 ml syrup every 1-2 hours to achieve a rapid effect (first bowel movement). Then move on to the maintenance dose, selecting her individually to get a soft chair 2-3 times a day. In the treatment of dysbiosis and to normalize the intestinal microflora: The drug testosterone blend 250mg is administered during or after a meal, 2 – 4 times a day.
The duration of treatment is 10-14 days, refresher courses are assigned to weekly intervals.
Side effects are usually bland and reversible and testosterone blend 250mg are a consequence of exceeding the dose. Cramping, pain or discomfort in the abdomen and diarrhea can be eliminated by dose reduction. Flatulence appearing at the beginning of treatment usually takes place at 1 -2 days. Cases of skin reactions (rash).
When long-term therapy with high doses of lactulose in the treatment of hepatic encephalopathy may develop a violation of water-electrolyte balance, and as a result, seizures, nausea, headache, dizziness, arrhythmia, myalgia, fatigue, and weakness.
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